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THO-dependent induction of ER-stress-associated programmed death of these cells results in the disruption of the ocular surface epithelial barrier, paving the way for the entrance of invading pathogens in the eyes of DED patients [46]

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Given the consistently elevated Max HR values observed in our study, we reasoned that RTT patients are usually considered fragile and motor-impaired paradoxically compared to young athletes under active dynamic exercise