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Direct Effects of Sorbitol as an Osmotic Stressor Sorbitol is an impermeable osmolyte that cannot cross cell membranes, so its accumulation imposes a direct osmotic stress that promotes cell swelling [27]

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Cytokine-induced intestinal injury Since various pro-inflammatory cytokines affect the integrity of the intestinal mucosa, oncologic conditions associated high levels of these cytokines are expected to be associated with a breach in the intestinal barrier functions

K.BlackintonJ.BeilinaA.Van Der BrugM.SandebringA.et al (2011)

CML, carboxymethyllysine