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Intracellular production of OH from H 2 O 2 is driven by the Fenton reaction, shown in Reaction 3 (43, 44, 48): As the most reactive known ROS, OH reacts with nearly all intracellular building blocks and macromolecules (amino acids, nucleic acids, phospholipids, sugars, proteins, RNA, DNA, lipids, polysaccharides)

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Hydrogen sulfide (H 2 S), which is produced in vivo from LC catalyzed by the enzyme CSE [137], plays a crucial role in regulating numerous cellular functions and biochemical processes