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RBDs from SARS-CoV-2, SARS-CoV-1, bat CoV RaTG13, and bat CoV WIV1 were genetically fused using linkers to I53-50A, allowing the display of 60 RBDs in a trimeric form in a vaccine named RBD-NP or GBP511 [145] (Table 2)

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For instance, ChIP sequencing data manifested that histone H3 phosphorylated at tyrosine 41 (H3Y41) presents in transcriptional start sites (TSS) function together with H3K4me3 which implicated in transcriptional activation [28]