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Although this was an open-label study, without a placebo control group, and as such has some limitations, the study results were able to demonstrate that taking ALA was linked to lower triglycerides, fewer neuropathic symptoms, and a better quality of life

and the advancement of innovative drug delivery systems, such as nanocarriers and hydrogels, that integrate strategies for regulating iron homeostasis, reducing inflammation, counteracting oxidative stress, and promoting cartilage regeneration

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NAC is a well-studied, Food and Drug Administration (FDA)-approved drug, with a favorable safety profile in neonates, giving these findings significant translational potential in the face of the opioid epidemic and rising rates of NAS after exposure to opioids in utero

So the risk of taking excessively high doses of B12 is mitigated as long as your kidneys are working (which is the case for many of you)