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Summary: The correct dosage of B12 for healthy UK adults is 1.5 micrograms daily for maintenance, whilst treatment of deficiency requires substantially higher doses of 1,0002,000 g orally or 1 mg intramuscular injections

International Journal of Radiation Oncology Biology Physics

Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

Usually avoid combinations

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In the treated group, the GSH level, SOD and CAT activities can decrease compared to the control group, thus explaining the increased oxidative stress in the spleen (Sengupta et al., 2017)