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Furthermore, disease models based on the transgenic expression of ALS-associated mutations in vivo have been used extensively to investigate ALS pathogenesis and motor neuron degeneration (Taylor et al., 2016)

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Source: ScienceDirect Topic Summary

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Coincidently, ATM is thought to regulate selective mitochondrial functions through NRF1 (a similar protein of the NRF2 family) in response to ROS 93

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