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Most of these changes are benign and self-limited, but others require further work-up for infectious etiologies or underlying systemic disorders

Melanin is the pigment substance that makes the skin darker and is produced in specialized cells throughout the skin called melanocytes

The authors also found that damage of actin filaments and microtubules increases the deformability contributing to motility and metastization (Gao, 2014)

In addition, renal and prostatic stones may form

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Tao Y, Wang Y, Yin Y, Zhang K, Gong Y, Ying H, et al