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doi: 10.2174/157488612802715663 62

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Mason, Free radical metabolites of L-cysteine oxidation

Tumor cells form a two-way connection with circumferent stroma in the early stage of invasion and after that, tumor-stroma interaction helps the tumor to develop toward metastasis ( Pre-Metastatic Niche An appropriate microenvironment, namely, pre-metastatic niche, can be established in secondary tissues and organs before metastases occurring through a complicated mechanism by interaction between the primary tumors and organs stromal components (92)

ALDHs are overexpressed in subpopulations of cancer cells with stem-like features, where they are involved in several processes including cellular proliferation, differentiation, detoxification and survival, participating in lipids and amino acid metabolism and retinoic acid synthesis

Abstract Cancer cells have adapted to rapid tumor growth and evade immune attack by reprogramming their metabolic pathways
