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Activation of TSPO promotes the production of endogenous neurosteroids, as in steroid synthesis and mitochondrial function

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The MHRA (2022) recently issued guidance on the increased risk of vitamin B12 deficiency in people treated with metformin, highlighting increased risks with higher metformin doses, longer treatment duration and in patients with risk factors for B12 deficiency, including the following: Existing low B12 levels

doi: 10.1038/nm.3933 [DOI] [PMC free article] [PubMed] [Google Scholar] 84

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The volumetric T1-weighted images were used for spectroscopic voxel placement and tissue segmentation
