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Results suggest that decreased PON1 activity seems to be associated with increased oxidative stress in patients with acetaminophen intoxication

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Thus, the most reactive hydroxyl radical is able to oxidize molecules such as DNA, phospholipids, and proteins, while the superoxide can generate other free radicals, as well as associate with nitric oxide (NO), and form the peroxynitrite radical (ONOO-), a powerful NO depleted oxidant

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