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[PMC free article] [PubMed] [Google Scholar] 4.Logozzi M., Mizzoni D., Di Raimo R., Andreotti M., Macchia D., Spada M., Fais S

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doi: 10.7759/cureus.26154

Beyond defects in antigen presentation, the harsh TME profoundly suppresses T-cell activation through a variety of cellular and soluble mediators

As the upregulation of p21 Cip1/WAF1 protein levels was no longer evident transfecting a dominant-negative form of c-fos (DN/c-fos) in both SkBr3 and Ishikawa cells (Figures 5c and d), we ascertained by chromatin immunoprecipitation assay that LA induces the recruitment of c-fos to the AP1 site located within the p21 Cip1/WAF1 promoter sequence (Figure 5e)

By encapsulating pharmacological agents and natural compounds, PLGA systems could overcome the shortcomings of conventional therapies and improve the therapeutic potential of phytochemicals