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Eur J Endocrinol 171(4):R137R152

In a study of 91 patients with AE who did not achieve adequate remission after RTX treatment, a retrospective analysis revealed that among the 30 patients who received TCZ, 89.5% experienced improvement in clinical symptoms within one month and maintained a favourable long-term clinical response [65]

Thus, although hyperglycemia and its associated tissue level modifications (e.g., glycation and fibrosis) are known to impair angiogenesis 61 , we cannot rule out a potential positive effect of ketonemia on our observed improvements in muscle remodeling and aerobic capacity

doi: 10.1128/AAC.01403-19

UCB exhibits a rapid increase in ER stress characteristics, including Ca2+ release, calpain, activation of JNK1/2, and the production of ROS, mitochondrial dysfunction, apoptosis, and necrosis [46]

doi: 10.1038/sj.mp.4001474