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When mitochondria are depolarized, the loss of mitochondrial membrane potential stabilizes PINK1 on the outer mitochondrial membrane (OMM), where it recruits and phosphorylates Parkin at serine 65 within its ubiquitin-like (UBL) domain, amplifying Parkins recruitment to the OMM [25]

Peak plasma concentrations after standard oral doses are in the low nanomolar range (typically 550 nM), far below the micromolar concentrations (150 M) used in most in vitro studies (165, 166)

For the ATD of intact LBD conformation, non-uniform refinement (C2 symmetry) followed by local refinement was used to obtain an ATD structure at 3.32 resolution

LWT Food Sci Technol 2022;161:18

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