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They are NOT for use as food additives, drugs, cosmetics, or other inappropriate applications

Long-term follow-up is required to fully assess the biologic behavior

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doi: 10.1074/jbc.M115.640128 164 BksMLangleyDRCrewsCM

Furthermore, macrophage polarization, caused by hyperglycemia and oxidative stress, is the major reason for delayed wound healing (Jiang et al., 2019)
