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In addition to the effects described, xenobiotic toxicants bound to PM can elicit a range of additional health impacts by amplifying the toxicological burden on the respiratory system, for example, interference with cellular signaling pathways through heavy metal compounds, impairing the repair mechanisms of lung tissue and promoting chronic inflammation [204]

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These DEGs were associated with neural differentiation in the central nervous system and regulation of immune system processes, molecular-level investigations revealed significant impacts of co-exposure to 4-MBC and PS-NPs on the transcriptome and proteome of zebrafish brains, involving multiple biological processes such as neuronal differentiation, immune regulation, and reproduction (62)