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The possible allosteric effect of reactive oxygen species on GPx enzyme can lead to an increased activity through increased lipid peroxidation ( Reference Levin, Cogan and Levy 40 )

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Furthermore, NAC normalized the altered GSH levels displayed by these animals in the hippocampus and nucleus accumbens, and it partially rescued the altered expression of post-synaptic terminal network genes found in VPA-exposed rats, such as NR2a, MGLUR5, GLUR1 , and GLUR2 in nucleus accumbens, and CAMK2, NR1 , and GLUR2 in cerebellum

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The GSH/GSSG ratio is a widely accepted indicator of oxidative stress and cellular redox balance

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However, other studies report more complicated associations between B vitamins and cancer (as also reviewed in ref

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[DOI] [PubMed] [Google Scholar] Blum R., Meyer K.C., Wnschmann J., Lendzian K.J., Grill E

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Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM (2018) Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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