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For each sensor, the cognate metal-affinity ( K 1 ), and the DNA-affinities of the apo- and metalated-protein ( K 3 and K 4 ) were measured in vitro (Fig

Further applying Seahorse extracellular flux assays, studies have demonstrated that the heightened mitochondrial respiration observed in CF cell lines, including HBE cells expressing CFTR F508del/F508del , can be remarkably normalized by triple CFTR modulator therapy through mechanisms involving calcium (Jarosz-Griffiths et al., 2024)

341,641 particles) (Supplementary Fig

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Two later randomized placebo-controlled trials with cancer patients were carried out at the Mayo Clinic (Moertel et al

Such stratification addresses pathological heterogeneity, a critical gap in current one-size-fits-all approaches