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Anti-angiogenic therapy: rationale, challenges and clinical studies

This review aims to summarize the role of the oxidative stress in the pathogenesis of AD, focusing in the main oxidative products (DNA, protein, and lipid oxidation products), as well as antioxidant therapeutic approaches involving natural products, nanomaterials, hydrogels, and microneedles

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The hydrolysis of Rab7 GTP at mitochondria-lysosome contact sites is driven by TBC1D15, which is a kind of Rab7 GTPase activating protein (GAP) and is recruited to the mitochondria via the mitochondrial extramembrane protein Fis1