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A partially purified leaf enzyme with DHAR activity was subsequently reported, but was considered likely to be cytosolic (Foyer and Halliwell 1977)

Severe hyperglycaemia may induce glucotoxicity in selective neurons involved in cognitive processing, with hippocampal neurons having been identified as particularly vulnerable to hyperglycaemia, and with proposed mechanisms including mitochondrial dysfunction and inflammatory responses [35]

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Over time, these changes could play a role in promoting better cardiovascular health

Several observational studies using similar formulations and instillation protocols ranging from weekly to monthly to PRN and follow-up intervals of a few months to several years reported efficacy rates of 25 to 90%