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Aroda VR, Edelstein SL, Goldberg RB et al (2016) Long-term metformin use and vitamin B12 deficiency in the diabetes prevention program outcomes study

Oxidative stress activates melanocytes, the cells responsible for producing melanin, and pushes them into overdrive

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The key practical point: if you run a clinic or a pharmacy, regulatory uncertainty is not an abstract phrase

Type 2 diabetes glucose control, usually alongside metformin

However, it's important to approach supplementation thoughtfully, considering dietary, lifestyle, and medical factors