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Int J Mol Sci 22(18):10136

found that the Nrf2/ARE pathway can inhibit the inflammatory infiltration of macrophages in autoimmune myositis rats [231]

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This reduced effect may be explained by the predominant presence of GluN1-GluN2A-GluN2B tri-heteromeric NMDAR in the hippocampus of neonatal and adult mice (Rauner and Khr, 2011), which, as observed in our recombinant system experiments, display significantly lower sensitivity to EAR-20