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Another essential area is the prenatal exposure effect of methamphetamine on the heart in adults

ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]

Zhang YE (2018) Mechanistic insight into contextual TGF- signaling

PMID: 33345139

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, et al

The authors of the study wrote that the potential mechanisms behind these effects include "L-carnitine's role in transporting fatty acids across mitochondrial membranes, enhancing beta-oxidation, reducing free fatty acid availability, and inhibiting cholesterol synthesis." In addition, the authors noted, "L-carnitine exhibits antioxidant and anti-inflammatory properties, which can further modulate dyslipidaemia (the imbalance in blood lipids) and protect LDL from oxidative stress." Finally, it was reported that L-carnitine was able to reduce the conversion of free fatty acids to triglycerides, and ultimately prevent the build-up of triglycerides