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10.1007/s00253-021-11622-2 112 DobbsS

There is research indicating that gynostemma pentaphyllum polysaccharides [167] and a flavonoid-rich extract of bergamot juice [168] further expand this paradigm: both alleviate hepatic inflammation through TLR pathway inhibition (TLR2/NLRP3 and TLR4/MyD88/NF-B/MAPK respectively), cytokine downregulation (TNF-, IL-1, IL-6), and gut barrier enhancementnotably reducing endotoxemia and improving intestinal permeability

established that T4 is indistinguishable from the platelet actin-sequestering peptide Fx, forming a 1:1 complex with actin monomers and inhibiting salt-induced polymerization