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Directional integration and pathway enrichment analysis for multi-omics data

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proposed classifying AN as a metabolic-psychiatric condition, indicating that it may respond to treatment with metabolic interventions that exhibit neuromodulatory properties [247]

The mitochondrial pool of acetyl-CoA is spatially distinct from acetyl-CoA found in the nucleus and cytosol due to the inability of acetyl-CoA to cross the inner mitochondrial membrane
