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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

Not for everything

Breastfeeding women: 2.8 mcg daily

Avoid using GLP-1 RAs if you have a personal or family history of medullary thyroid carcinoma or MEN2 syndrome (Multiple endocrine neoplasia type 2 syndrome)

B12 Sources If you are looking to get more B12 through dietary sources, there are a couple of good options

Is AOD-9604 approved by the FDA