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Rheumatoid arthritis (RA) is a chronic inflammatory and systemic disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone that lead to joint destruction

There may be increased entry of ammonia into the central nervous system due to increased permeability of the bloodbrain barrier and conversion of positively charged ammonium ion to ammonia, which more readily crosses the bloodbrain barrier, secondary to changes in blood pH

In other words, Is it safe? is often less about the concept of peptides and more about the execution of peptide therapy