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Statistical Analysis Data were analyzed using GraphPad Prism 8 (GraphPad Software, San Diego, CA, USA)

In other cases, the deconjugation may simply be due to reversal of the conjugation reaction

Unpredictable or missed menstrual periods, along with normal or elevated E2 (Estradiol) levels and often high E1 (Estrone) levels, may indicate polycystic ovarian syndrome (PCOS), an underlying medical condition

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Author contributions Conceptualization, YZ, WL, and ML

Experimental and therapeutic medicine
