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Pluripotency of the established iPSC lines was confirmed by standard assays for iPSC markers and differentiation potential

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1b, 5), which can be synthesised starting from modified furans in a one-pot synthesis 30,31

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Taxonomical annotation was performed by mapping the reads against the NCBI non-redundant protein database using Kaiju (v1.7.3) (Menzel et al., 2016)

Individuals were excluded if they had a vasectomy, Y-chromosome microdeletions, Klinefelter syndrome, cystic fibrosis, physical impairments leading to infertility, or used fertility-related medicines in the past six months