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128 The following trials showed satisfactory safety and tolerability of PBT2 in AD patients

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1), murine Wnt3a (100 ng/ml

Using the 10 mg/mL solution, the required volume is 2 mg 10 mg/mL = 0.2 mL , which corresponds to 20 units on the insulin syringe

Although currently mostly in preclinical studies, this co-delivery strategy is expected to gradually move toward clinical application as delivery systems improve and more pharmacokinetic/toxicological data accumulate (Table 4)