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doi: 10.1038/onc.2017.11 58 BattagliaAMSaccoAPerrottaIDFanielloMCScaliseMTorellaDet al

ACNs are responsible for the red, purple and blue colors of many flowers, cereal grains, fruit, and vegetable

Furthermore, peroxidated lipids can be decomposed into toxic derivatives, which may induce significant cytotoxicity (43, 44)

2 Initiation phase: uric acid supersaturation in body fluids and altered physicochemical conditions 2.1 Causes of hyperuricemia and its effects on the local microenvironment The fundamental pathophysiological basis of tophus formation is the persistent elevation of serum uric acid above its solubility threshold, leading to urate supersaturation

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Prompt medical evaluation is necessary if such symptoms occur