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Key Takeaways NAD+ and glutathione work together as a powerful cellular support system, addressing energy production, detoxification, and age-related decline through complementary biochemical pathways

Thus, despite the demonstrated senolytic effects of BCL-2 family inhibitors, their clinical translation is limited due to potential side effects, off-target effects on platelets and poor central nervous system (CNS) penetrance

Yu D, Wu Y, Shen H, Lv M, Chen W, Zhang X, et al

& Kineman, R

The active GSH rapidly oxidizes into the inactive GSSG

However, in FUS-induced ALS/FTD, FUS is hypomethylated and accumulates in neurons as both nuclear and cytoplasmic aggregates