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NAPQI modifications of certain proteins can alter critical cellular functions (Liebler, 2008) and NAPQI-protein adducts have been found to accumulate in hepatocytes (Jollow et al., 1973)

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Eggleton P, Reid KBM (1998) C1q - how many functions

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Therefore, ginsenosides mainly reduce the hepatotoxicity of APAP by inhibiting oxidative stress