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This was mediated through disruption of microbiota-gut-brain axis homeostasis, specifically manifested as reduced production of serotonin (5-HT) in the gut, leading to lower levels transported to the brain via the bloodstream, ultimately contributing to neurobehavioral deficits

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Fcy::Fur fusion catalyzes transformation processes wherein five-fluorocytosine (5-FC) is converted selectively, yielding toxic derivatives known as five-fluorouracil (5-FU), effectively targeting only malignant cellular populations without adversely affecting surrounding healthy tissue structures (85)

Cell Reports 30 (12), 3964-3971.e.7 (2020)