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Johansen, P., von Moos, S., Mohanan, D., Kndig, T

Cytotoxicity of metal-based nanoparticles: from mechanisms and methods of evaluation to pathological manifestations

Kitani, T., Kuratsune, H

[DOI] [PMC free article] [PubMed] [Google Scholar] Kim Y.-I

Indeed, there is growing recognition that the GBA is a critical regulator of neurological functions and an intermediary to neurotoxicity by environmental stressors such as drugs, environmental contaminants, and dietary factors [115]

According to the current paradigm, glutamate-driven excitotoxicity, activation of calcium-dependent proteases, over activation of calcium-regulated kinases and phosphatases, and mitochondrial calcium overload resulting in mPTP opening (53, 54) are some of the mechanisms by which generalized calcium overload in neurons causes neuronal death (54, 55)