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It reduces the expression of chemokines MCP-1 and RANTES, which are essential for TAM recruitment, and further suppresses TAM activation by decreasing M2 macrophage markers and tumor-promoting factors like MMP-2, MMP-9, and VEGF

Animal model, induction method, mechanisms of action, and main targets of each disorder The use of animals in scientific research has long been a cornerstone of biological and medical studies, though it remains a subject of significant ethical debate

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Diabetologia (2012) 55:256582