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To understand the physiological role of each receptor, recognition of their specific ligands is necessary

On the other hand, it must be stressed that the above values are averages and there might be significant spatial heterogeneity 57

Consequently, harmful substances in the bloodincluding immune cells, inflammatory mediators, and large molecular proteinscan infiltrate spinal cord tissue, establishing a vicious cycle that perpetuates and amplifies tissue damage (Xin et al., 2023)