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Description
Clinical Trials of topical JAK inhibitor Ruxolitinib cream met the primary endpoint in both pivotal phases 3 clinical trials with critical secondary endpoints, with a significantly higher proportion of the trial group achieving at least 75% improvement in the F-VASI score (a quantitative measure to assess skin symptoms in patients with vitiligo) relative to baseline than the placebo group at week 24 of treatment (118)
A glycolytic shift in Schwann cells supports injured axons
Free Radical Biology and Medicine, 47(2), 184-188

Additionally, the mutated variant disrupts the physiological ferrireductase activity and leads to dysregulation of iron metabolism (1315) and membrane lipid oxidation (5)

Per NCCI 2026, one joint equals one unit

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