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In addition, double knockouts of PGC-1 and PGC-1 in skeletal muscle or the adult heart did not result in a loss in mitochondrial mass, which indicated that PRC may play a role in mitobiogenesis in the absence of PGC-1 and PGC-1 [71, 72], a finding that warrants further investigation

Eur J Pharmacol (2021) 910:174500

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In youth, dendritic spine turnover is relatively high and produces a net loss of spines

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