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elegans a suitable and convenient in vivo model to identify obesity-promoting compounds or to assess the lipid-lowering capacity of natural products, which could facilitate the prevention of obesity and the identification of potential anti-hyperlipidemic drugs [21,22]

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Unlike antagonists, agonist pharmacoperones do not need to dissociate from the receptor protein after rescue, albeit the potential problem of promoting receptor desensitization and internalization should be considered since this may provoke decreased response to the endogenous ligand

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