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By restoring hepatic lipid handling, bile acid metabolism, and mitochondrial oxidative capacity, AX reinforces the functional integration of the liveradiposemuscle axis, a key determinant of metabolic homeostasis disrupted in obesity

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Diabetes Care 2021 Sam S, Edelstein SL, Arslanian SA, Barengolts E, Buchanan TA, Caprio S, Ehrmann DA, Hannon TS, Tjaden AH, Kahn SE, Mather KJ, Tripputi M, Utzschneider KM, Xiang AH, Nadeau KJ, RISE Consortium

Ans: Yes

Rather than causing a frank decrease in complex III function, this mutation appears to result in delayed assembly of the I,III,IV supercomplex, 43 thus influencing the interaction of complex III with other complexes rather than specifically affecting only complex III

doi: 10.1007/s12035-016-0293-5