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In contrast, MEL does not display redox cycling, thus, it does not stimulate oxidation

The ratio of glutathione (GSH) to oxidised glutathione (GSSG) is a key indicator of cellular oxidative stress

Oncogene 23 , 85208526 (2004)

Expression of senescence enhanced genes in response to oxidative stress

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Another pathway is shared with ROS by the activation of NFE2L2 expression, which is the master regulator of antioxidant response upon oxidative burst and mitochondrial biogenesis upon exercise in muscle [75]