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(2024) JAMA Netw Open, 7: e243127.(335)West M, et al

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Neuron 19(3):653664

Interestingly, the neuroprotective effects of memantine were reported to be mediated by enhancing the astroglial system activity (Okada et al., 2019)

In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

New strategies for the development of antifungal drugs have gradually become a research hotspot, including the targeting of novel biological pathways, the combination of antifungal drugs, the development of fungal vaccines, the creation of innovative therapeutics (such as small-molecule peptides and nanoparticles), the extraction of active ingredients from traditional Chinese medicine, and the utilization of artificial intelligence in drug design ( Figure 1 ) (Wall and Lopez-Ribot, 2020