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Mitoma H, Horiuchi T, Tsukamoto H, Ueda N

Notably, RRMS patients had a much greater frequency of the NLRP3 rs3806265 C allele and CC genotype than did relapse patients and healthy controls, but remission patients had a significantly lower frequency, which demonstrated that these modifications in NLRP3-related molecular gene polymorphisms were linked to MS susceptibility [80]

Microneedling before application is used in some protocols to improve penetration, though this is based on mechanistic reasoning more than direct comparative RCT data

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Neuropsychopharmacology 44:235236

Choi S, Hong SP, Bae JH, et al