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CSE is a highly inducible protein and can be regulated by several factors depending on the cell type and tissue (Figure 2C)

Role of intrarenal angiotensin system activation, oxidative stress, inflammation, and impaired nuclear factor-erythroid-2-related factor 2 activity in the progression of focal glomerulosclerosis

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Functional consequences of the disruption of -globin-eNOS binding via an -globin mimetic peptide have been observed ex vivo, by increased NO sensitivity of isolated small arteries from mice and humans (124, 166), and in vivo, in lowering of systemic blood pressure in mice (164)

The peptide is derived from a partial sequence of a larger protein identified in human gastric juice, first characterized in the early 1990s

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