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It promotes neurogenesis and enhances the action of neurotrophic factors. An ongoing clinical trial (NCT03641404) testing ergothioneine supplementation (25 mg three times weekly) in elderly individuals with mild cognitive impairment shows promising preliminary results: Significant increases in blood ergothioneine levels Improvements in global cognitive performance scores Trending improvements across multiple cognitive assessments Reduction in neurofilament light protein (a marker of neuronal injury) Recent 2025 research revealed that ergothioneine significantly increases brain-derived neurotrophic factor (BDNF) expression in nerve cells [8]

Nachtarbeiter Leber und Galle Die Leber ist das Organ der Wandlung, Vernderung und Erneuerung auf krperlicher sowie seelisch-geistiger Ebene

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[DOI] [PubMed] [Google Scholar] 548.Gascon S., Murenu E., Masserdotti G., Ortega F., Russo G.L., Petrik D., Deshpande A., Heinrich C., Karow M., Robertson S.P., Schroeder T., Beckers J., Irmler M., Berndt C., Angeli J.P., Conrad M., Berninger B., Gotz M

Furthermore, cafestol has been reported to protect cellular DNA from genotoxic agents