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doi: 10.1038/sj.bjc.6601195

Barrier Disruption by Specific Microbes Intestinal pathobionts are often overrepresented in the microbiota of patients with inflammatory disorders, where they accelerate systemic inflammation by translocating across the epithelial barrier to reach extraintestinal tissue ( Figure 1 )

Understanding the right way to approach their use in a lab setting is the first, critical step

Furthermore, the culture model significantly influences the cellular response in hyperosmotic environments: AD-MSCs showed stronger tolerance in monolayer culture, but their tolerance to hyperosmotic environments was significantly reduced in 3D suspension or hydrogel cultures (Potocar et al., 2016)

Molecular dynamics helps us narrow down particular regions that we want to focus on to develop therapeutics. The MIT team then used peptide synthesis technology that Pentelutes lab has previously developed, to rapidly generate a 23-amino acid peptide with the same sequence as the alpha helix of the ACE2 receptor

Quigley EM