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Unnoticed lesions and incorrect delineations can lead to tumor recurrence or iatrogenic tissue damage

Although CYP2E1 is abundant in the liver, it also presents in the brain, kidney, skin, heart, lung, and skeletal muscle [2, 6]

Blood 129, 27192726

Ferroptosis is an iron-dependent, non-apoptotic form of cell death characterized by lipid peroxidation-driven loss of plasma membrane integrity, primarily mediated through three interconnected mechanisms: iron metabolism dysregulation, glutathione peroxidase 4 (GPX4) inactivation with concomitant glutathione depletion, and lipoxygenase (LOX)-catalyzed lipid peroxidation

The action of MDA may be tissue-dependent

, Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II