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Beyond that, the evidence is per-compound plus the CagriSema (cag + sema) Phase 3 data as the closest human analog

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Through a comprehensive analysis of the groundbreaking progress achieved by nanocarriers in enhancing oral drug bioavailability, improving tumor-targeting specificity, and enabling microenvironment-regulated drug release, we aim to provide novel insights and a robust theoretical foundation for the development of next-generation intelligent NDDS

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for instance, the DsbA tag offers specific utility for disulfide-bonded proteins, while SlyD may act as an intrinsic chaperone

Therefor TRM might be the potential target to enhance immunological protection
