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Apart from its role in DNA methylation, folate exhibits antioxidant properties that have been found to regulate the proliferation of cancer cells through three main mechanisms: (i) enhances the coupling of eNOS to cofactor tetrahydrobiopterin (BH4), hence inhibiting the formation of superoxide anion and the resulting peroxynitrite, a potent oxidant involved in various pathological conditions

Patients often present with symptoms that affect multiple organ systemsranging from Raynauds phenomenon, inflammatory myopathy, and pulmonary hypertension, to sclerodactyly and esophageal dysmotility

doi: 10.1186/s12877-020-1472-9 543 JoynerMJ

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Toxins 13:314

Nordic Adaptation of Classification of Occupationally Related Disorders to ICD-10